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KMID : 0043319950180050295
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Archives of Pharmacal Research
1995 Volume.18 No. 5 p.295 ~ p.300
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Effects of Ginsenosides on the Glutamate Release and Intracellular Calcium Levels in Cultured Rat Cerabeller Neuronal Cells
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Oh Sei-Kwan
Kim Hack-Seang
Seong Yeon-Hee
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Abstract
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These studies were designed to examine the effects of ginsenosides on glutamate neurotansmission. In primary cultures of rat cerebellar granule cells, ginsenosides (Rb1, Rc did not Rg1, ) increased glutamate release which was measured by HPLC. but HPLC, but Re did not shwo an elevation of glutamate release. However, all of these ginsenosides down-regulated N-methyl-D-aspartate (NMDA)-induced glutamate release. Rc strongly increased glutamate release and elevated intracellular clcium concentrations which was measured by ratio fluorometry with FURA-2AM. These results indicate that ginsenosides have a homeostatic effect on glutamate neurotransmission, and there is a structure-function relationship among the ginsenosides tested.
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KEYWORD
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Ginsenoside, Cerebellar granule cells, Glutamate, N-methyl-D-aspartate(NMDA)
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